E-JOURNAL

Lung cancer risk and occupational pulmonary fibrosis: systematic review and meta-analysis

---

Abstract
Background: Molecular pathways found to be important in pulmonary fibrosis are also involved in cancer pathogenesis, suggesting common pathways in the development of pulmonary fibrosis and lung cancer.

Research question: Is pulmonary fibrosis from exposure to occupational carcinogens an independent risk factor for lung cancer?

Study design and methods: A comprehensive search of PubMed, Embase, Web of Science and Cochrane databases with over 100 search terms regarding occupational hazards causing pulmonary fibrosis was conducted. After screening and extraction, quality of evidence and eligibility criteria for meta-analysis were assessed. Meta-analysis was performed using a random-effects model.

Results: 52 studies were identified for systematic review. Meta-analysis of subgroups identified silicosis as a risk factor for lung cancer when investigating odds ratios for silicosis in autopsy studies (OR 1.47, 95% CI 1.13-1.90) and for lung cancer mortality in patients with silicosis (OR 3.21, 95% CI 2.67-3.87). Only considering studies with an adjustment for smoking as a confounder identified a significant increase in lung cancer risk (OR 1.58, 95% CI 1.34-1.87). However, due to a lack of studies including cumulative exposure, no adjustments could be included. In a qualitative review, no definitive conclusion could be reached for asbestosis and silicosis as independent risk factors for lung cancer, partly because the studies did not take cumulative exposure into account.

Interpretation: This systematic review confirms the current knowledge regarding asbestosis and silicosis, indicating a higher risk of lung cancer in exposed individuals compared to exposed workers without fibrosis. These individuals should be monitored for lung cancer, especially when asbestosis or silicosis is present.

---

Ketersediaan

P00101S

My Library

Tersedia

Informasi Detil

Judul Seri

-

No. Panggil

-

Penerbit

Swiss : ERJ., 2024

Deskripsi Fisik

-

Bahasa

English

ISBN/ISSN

10.1183

Klasifikasi

NONE

Tipe Isi

text

Tipe Media

computer

Tipe Pembawa

-

Edisi

vol 33 no 171

Subyek

Respiratory Disease
OHS

Info Detil Spesifik

-

Pernyataan Tanggungjawab

-

Versi lain/terkait

Lampiran Berkas

Komentar

---

You must be logged in to post a comment